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Implants induce a new niche for microbiomes
Tim H Jakobsen1, Steffen R Eickhardt1, Alexandra G Gheorghe2
1Costerton Biofilm Center, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark.
Summary
Microbial colonization is common on clinically uninfected medical implants, with both bacteria and fungi frequently detected. This suggests implants alter the human microbiome by creating new niches for microbes.
Area of Science:
- Microbiology
- Biomedical Engineering
- Medical Science
Background:
- Understanding microbial colonization on medical implants is crucial for preventing infections.
- Knowledge gaps exist regarding the prevalence of microorganisms on clinically uninfected implants.
Purpose of the Study:
- To detect and identify bacteria and fungi on implants from patients without signs of infection.
- To investigate microbial colonization in various patient groups with implants.
Main Methods:
- Microbiological detection methods were used to analyze 106 clinically uninfected implants and 39 negative controls.
- Samples were collected from five hospitals in Denmark across four patient groups.
Main Results:
- 66% of implants showed bacterial colonization, and 40% showed fungal colonization.
- Prevalent microbes were not typical causes of implant infections.
- Significant microbial colonization was observed compared to negative controls (p < 0.0001).
Conclusions:
- Medical implants serve as distinct niches for microbial colonization.
- The presence of implants can alter the human microbiome.
- Further research is needed to understand the clinical implications of this colonization.
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