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Successful Treatment for Severe Thyroid-associated Ophthalmopathy with Tocilizumab
Carlos A Canas1, Fabio Bonilla-Abadia1, Katherine Vallejo1
1GIRAT: Grupo de investigacion en Reumatologia, Autoinmunidad y Medicina Traslacional, Fundacion Valle del Lili and Universidad Icesi, Cali, Colombia.
Background And Objective:
Thyroid-associated ophthalmopathy (TAO) is the most common extrathyroidal manifestation of Graves disease, occasionally severe and refractory to treatment, mainly in long-term disease. In these cases, one of the most important infiltrating cytokines in the orbital tissue is interleukin-6 (IL-6).
Methods:
This is a case report, the methodology consisted of the application of tocilizumab in a patient with graves disease and the patient's follow-up.
Results:
We present the case of a 54-year-old male with TAO who responded adequately to treatment with tocilizumab, an antibody directed against the IL-6 receptor.
Conclusion:
Tocilizumab could be an optional treatment in patients with TAO.
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