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Related Experiment Videos

Diagnosing infectious mononucleosis.

J A McSherry

    American Family Physician
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing infectious mononucleosis requires clinical signs, lymphocytosis, and atypical lymphocytes. A positive serologic test confirms diagnosis, but high atypical lymphocyte counts can be diagnostic alone.

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    Area of Science:

    • Medical diagnostics
    • Hematology
    • Virology

    Background:

    • Infectious mononucleosis is a common viral illness.
    • Accurate diagnosis relies on a combination of clinical and laboratory findings.

    Purpose of the Study:

    • To outline the diagnostic criteria for infectious mononucleosis.
    • To clarify the role of serologic testing in diagnosis.

    Main Methods:

    • Review of clinical and laboratory diagnostic parameters for infectious mononucleosis.
    • Analysis of lymphocyte counts and morphology in suspected cases.

    Main Results:

    • Diagnosis requires clinical findings, lymphocytosis, and lymphocyte atypia (>20%).
    • A positive serologic test is typically necessary for confirmation.

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  • Lymphocyte atypia exceeding 40% is highly specific and may obviate serologic testing.

    • Conclusions:

    • Infectious mononucleosis diagnosis is definitive with corroborating clinical and laboratory data.
    • High levels of atypical lymphocytes are a strong indicator, potentially simplifying diagnosis.