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Updated: Feb 8, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
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l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP

Lamia Heikal1, Anna Starr1, Dania Hussein1

  • 1Institute of Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

JACC. Basic to Translational Science
|July 3, 2018
PubMed

Keywords:
ACh, acetylcholineANOVA, analysis of varianceBH2, dihydrobiopterinBH4, tetrahydrobiopterinEC50, effective concentration for 50% maximal responseEDHF, endothelium derived hyperpolarizing factorGCH1, GTP cyclohydrolase-1GFRP, GCH1 feedback regulatory proteinL-phe, l-phenylalanineL-tyr, l-tyrosineNO, nitric oxideROS, reactive oxygen speciesSHR, spontaneously hypertensive rat(s)WKY, Wistar Kyoto rat(s)cardiovascular diseaseeNOS, endothelial nitric oxide synthaseendotheliuml-phenylalaninenitric oxidetetrahydrobiopterinvascular activity

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