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Malignant transformation of eccrine spiradenoma.
Archives of Dermatology
|November 1, 1985
Summary
Malignant transformation in eccrine spiradenoma presents a distinct clinical and pathological profile. This rare event involves atypical basaloid cells within long-standing skin nodules, sharing features with dermal cylindroma transformation.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Eccrine spiradenoma is a benign adnexal neoplasm.
- Malignant transformation of benign skin tumors is a rare but significant event.
Observation:
- Two cases of malignant transformation within eccrine spiradenoma are presented.
- Clinicopathologic findings were compared with six similar cases from the literature.
Findings:
- A characteristic pattern emerged, including rapid enlargement of long-standing cutaneous nodules.
- Neoplasms featured atypical basaloid cells with high mitotic activity.
- Microscopic examination revealed adjacent benign spiradenoma and retained architectural features of the original tumor.
Implications:
- Malignant eccrine spiradenoma shares features with malignant dermal cylindroma.
- Understanding this transformation is crucial for accurate diagnosis and patient management.
- Further follow-up is needed for prognosis in some cases.