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Updated: Feb 8, 2026
09:21
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
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Targeted Therapy-based Combination Treatment in Rhabdomyosarcoma
Anke E M van Erp1, Yvonne M H Versleijen-Jonkers1, Winette T A van der Graaf2,3
1Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Molecular Cancer Therapeutics
|July 4, 2018
Summary
Targeted therapies show promise for rhabdomyosarcoma but resistance is common. Combining therapies targeting distinct mechanisms may overcome resistance and improve outcomes for alveolar (ARMS) and embryonal (ERMS) rhabdomyosarcoma.
Area of Science:
- Oncology
- Pharmacology
Background:
- Alveolar (ARMS) and embryonal rhabdomyosarcoma (ERMS) are pediatric soft-tissue sarcomas with limited treatment progress.
- Insulin-like growth factor 1 receptor (IGF1R)-directed therapy shows some activity but is often limited by resistance.
Purpose of the Study:
- To review preclinical and early clinical data on targeted therapy combinations for ARMS and ERMS.
- To identify promising combination strategies to overcome treatment resistance and enhance efficacy.
Main Methods:
- Comprehensive overview of targeted therapy combinations in rhabdomyosarcoma.
- Focus on therapies targeting receptor tyrosine kinases, Hedgehog pathway, apoptosis, DNA damage response, cell-cycle regulators, fusion proteins, and epigenetic modifiers.
Main Results:
- Targeted therapies offer potential but often face resistance in ARMS and ERMS.
- Combination strategies are being explored to improve clinical outcomes.
Conclusions:
- Combination treatments, especially those simultaneously targeting distinct mechanisms, hold promise for overcoming resistance in ARMS and ERMS.
- Further investigation into rational combination therapies is crucial for improving pediatric rhabdomyosarcoma treatment.
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