Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metrizamide brain penetrance.

B P Drayer1, A E Rosenbaum

  • 1Neuroradiology Division, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, Pennsylvania 15261.

Acta Radiologica. Supplementum
|January 1, 1977
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistance training reduces susceptibility to eccentric exercise-induced muscle dysfunction in older women.

The journals of gerontology. Series A, Biological sciences and medical sciences·2001
Same author

Radiation doses to infants and adults undergoing head CT examinations.

Medical physics·2001
Same author

In re: Amundsen P. Cerebral angiography via the femoral artery with particular reference to cerebrovascular disease. Acta Neurol Scand 1967; Suppl. 31:115.

AJNR. American journal of neuroradiology·2001
Same author

Cerebrovascular disease. American College of Radiology. ACR Appropriateness Criteria.

Radiology·2000
Same author

Progressive neurological deficit. American College of Radiology. ACR Appropriateness Criteria.

Radiology·2000
Same author

Epilepsy. American College of Radiology. ACR Appropriateness Criteria.

Radiology·2000
Same journal

Aspects of temporal bone anatomy and pathology in conjunction with cochlear implant surgery.

Acta radiologica. Supplementum·2003
Same journal

Contrast-enhanced magnetic resonance angiography: development and optimization of techniques for paramagnetic and hyperpolarized contrast media.

Acta radiologica. Supplementum·2003
Same journal

Magnetic resonance imaging in dementia. A study of brain white matter changes.

Acta radiologica. Supplementum·2002
Same journal

Radiation dose and image quality in diagnostic radiology. Optimization of the dose-image quality relationship with clinical experience from scoliosis radiography, coronary intervention and a flat-panel digital detector.

Acta radiologica. Supplementum·2002
Same journal

On contrast-enhanced magnetic resonance angiography of the aortoiliac arteries.

Acta radiologica. Supplementum·2002
Same journal

Aspects in mammographic screening. Detection, prediction, recurrence and prognosis.

Acta radiologica. Supplementum·2002
See all related articles

Serial CT cisternography with metrizamide (Amipaque) reveals normal cerebrospinal fluid flow and brain penetration. Adverse reactions correlate with peak penetration, impacting diagnostics.

Area of Science:

  • Neuroradiology
  • Neuroimaging
  • Pharmacokinetics

Background:

  • Cerebrospinal fluid (CSF) dynamics are crucial for neurological health.
  • Metrizamide (Amipaque) is a contrast agent used in neuroradiology.
  • Understanding contrast agent behavior in the CNS is vital for diagnostic accuracy.

Purpose of the Study:

  • To describe normal cerebrospinal fluid flow using CT cisternography.
  • To evaluate the brain penetration of intrathecally administered metrizamide.
  • To correlate adverse reactions with metrizamide's CNS penetration.

Main Methods:

  • Serial CT cisternography in 25 individuals.
  • Gross autoradiography with 131I-labelled metrizamide.
  • Monitoring of adverse reactions and EEG alterations.

Related Experiment Videos

Main Results:

  • CT cisternography demonstrated normal CSF flow patterns.
  • Autoradiography confirmed metrizamide penetration into brain substance.
  • Adverse reactions (headache, nausea, perceptual aberrations) peaked during maximum brain penetration.
  • EEG alterations were also observed.

Conclusions:

  • Metrizamide effectively visualizes CSF flow and penetrates the brain.
  • Adverse reactions are linked to the extent of metrizamide brain penetration.
  • Cerebral and cerebellar penetration of metrizamide has diagnostic value.