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Updated: Feb 8, 2026

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TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW

Ricardo Londono1, Aaron X Sun1,2,3, Rocky S Tuan1,3

  • 1Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Current Pathobiology Reports
|July 4, 2018
PubMed
Summary

Mammals typically form fibrotic scar tissue instead of regenerating limbs. Lower species like salamanders regenerate tissues through epimorphic regeneration, involving blastema formation.

Keywords:
blastemaregeneration“epimorphic regeneration”“regenerative medicine”“super-healing organisms”“wound healing”

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