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The Pathology of Type II Modic Changes: Fat Deposition or Osteosclerosis? A Study Using CT Scan
Chi Sun1, Hongli Wang1, Jianyuan Jiang1
1Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China.
Biomed Research International
|July 4, 2018
Summary
Type II Modic changes (MCs) show higher CT values, indicating osteosclerosis. Increased disc degeneration severity correlates with greater osteosclerosis in MCs.
Area of Science:
- Spinal imaging and diagnostics
- Degenerative disc disease research
- Bone marrow pathology
Background:
- Modic changes (MCs) are common findings on spinal MRI.
- Type II MCs represent fatty degeneration of bone marrow.
- The relationship between type II MCs and adjacent disc degeneration requires further clarification.
Purpose of the Study:
- To evaluate computed tomography (CT) values in type II Modic changes (MCs).
- To determine the association between CT values of type II MCs and adjacent disc degeneration severity.
Main Methods:
- Retrospective cross-sectional study of 124 type II MCs from 66 patients' MRI and CT scans.
- Disc degeneration graded using the Pfirrmann classification.
- CT values measured in MC regions, adjacent non-MC areas, and L1 vertebra; CT value changes (ΔCT) calculated.
Main Results:
- Type II MCs exhibited significantly higher CT values than non-MC regions in both bone marrow and endplate.
- A positive correlation was observed between the severity of adjacent disc degeneration (grade V vs. IV) and the ΔCT value at the endplate.
- The L1 vertebra served as a valid control for CT value comparisons.
Conclusions:
- Type II Modic changes may be associated with osteosclerosis.
- The degree of osteosclerosis within type II MCs appears to increase with the severity of adjacent disc degeneration.
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