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Updated: Feb 8, 2026

Multifocal Electroretinograms
Published on: December 4, 2011
Multifocal osteolysis with chylous polyserositis and intrathoracic vein thrombosis: a diagnostic challenge for
Kanon Jatuworapruk1, Ratchaya Lertnawapan1, Hataiwan Ratanabunjerdkul2
1Division of Rheumatology, Thammasat University, Pathum Thani, Thailand.
Abstract:
Vanishing bone disease with multisystemic involvement may mimic systemic autoimmune or autoinflammatory diseases. We present a 19-year-old man who was hospitalized due to chest pain following a progressive osteolysis of the bony thorax. The disease later expanded into the pleura, peritoneum and pericardium in a form of massive chylous polyserositis. The patient also developed thrombosis of multiple central veins, which in turn worsened the chylothorax by increasing the pressure in the thoracic duct. This is the first case of vanishing bone disease complicated by triple chylous effusions and central vein thrombosis.
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