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Self-serving bias is a cognitive phenomenon in which individuals attribute positive outcomes to internal factors such as their abilities, intelligence, or effort while attributing negative outcomes to external circumstances. This cognitive distortion helps maintain self-esteem but can also impede objective self-assessment.Theoretical Explanations of Self-Serving BiasTwo primary theories explain the self-serving bias: the cognitive explanation and the motivational explanation.The cognitive...
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Cadherins: cellular adhesive molecules serving as signalling mediators.

Mark Yulis1, Dennis H M Kusters1, Asma Nusrat1

  • 1Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA.

The Journal of Physiology
|July 4, 2018
PubMed
Summary

Cadherins are crucial transmembrane proteins regulating cell adhesion and signaling. Their diverse roles in cellular homeostasis, development, and disease highlight their significance in cell function.

Keywords:
AdhesionApoptosisCadherinDifferentiationProliferationProtein Cleavage

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cadherins are single-pass transmembrane proteins essential for intercellular adhesion.
  • Beyond adhesion, cadherins play significant roles in cellular signaling pathways.
  • These signaling events are critical for maintaining cellular homeostasis.

Purpose of the Study:

  • To explore the multifaceted roles of cadherin-mediated signaling.
  • To highlight the involvement of various cadherin types in cellular functions.
  • To underscore the broad impact of cadherins in biological processes.

Main Methods:

  • Review of existing literature on cadherin function.
  • Analysis of studies focusing on classical, desmosomal, and atypical cadherins.
  • Examination of cadherin involvement in signaling pathways.

Main Results:

  • Cadherins regulate critical signaling events controlling cellular homeostasis.
  • Examples include classical, desmosomal, and atypical cadherins.
  • Cadherin signaling impacts development, proliferation, apoptosis, and disease.

Conclusions:

  • Cadherin-mediated signaling operates through diverse molecular mechanisms.
  • The full extent of cadherin roles in signaling and cellular function is still being uncovered.
  • Cadherins are versatile proteins with broad implications in cell biology.