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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Sensorineural Deafness Following Tacrolimus Use.

Boju Sangeetha Lakshmi1, Bhukya Vidya, Mogili Hari Krishna Reddy

  • 1From the Department of Nephrology, Sri Venkateswar Institute of Medical Sciences, Tirupati, India.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|July 4, 2018
PubMed
Summary
This summary is machine-generated.

Tacrolimus, used in organ transplants, may cause hearing loss. A sudden increase in tacrolimus serum levels, combined with its cumulative toxic effect, is the likely cause of deafness in patients.

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Area of Science:

  • Nephrology
  • Otolaryngology
  • Pharmacology

Background:

  • Tacrolimus is an immunosuppressant commonly used in renal transplant recipients.
  • Previous studies have not identified hearing loss as a common adverse effect of tacrolimus therapy.

Observation:

  • This report details a case of deafness in a renal transplant recipient undergoing tacrolimus treatment.
  • A review of existing literature was conducted to identify similar cases and potential mechanisms.

Findings:

  • The case and literature review suggest a correlation between tacrolimus use and hearing loss.
  • A sudden spike in tacrolimus serum levels, followed by cumulative toxicity, is hypothesized as the primary cause.

Implications:

  • Clinicians should be vigilant for auditory adverse effects in patients treated with tacrolimus.
  • Monitoring tacrolimus serum levels and considering ototoxicity are crucial for patient management.
  • Further research is warranted to elucidate the precise mechanisms of tacrolimus-induced ototoxicity.