Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.7K

Associations Between MTHFR Polymorphisms and the Risk of Potentially Malignant Oral Disorders

Thomas Senghore1, Yu-Feng Li2, Fung-Chang Sung3

  • 1School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan, R.O.C.

Anticancer Research
|July 5, 2018
PubMed
Abstract

Insights

The T allele of the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant may lower the risk of potentially malignant oral disorders (PMODs). This protective effect was also observed with a specific MTHFR haplotype.

Area of Science:

  • Genetics
  • Oral Pathology
  • Molecular Biology

Background:

  • Potentially malignant oral disorders (PMODs) represent a significant health concern.
  • Genetic factors, including MTHFR gene polymorphisms, are increasingly recognized for their role in disease susceptibility.
  • Understanding the genetic basis of PMODs is crucial for risk assessment and prevention.

Purpose of the Study:

  • To investigate the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T and A1298C) and the risk of developing potentially malignant oral disorders (PMODs).

Main Methods:

  • Genotyping of MTHFR C677T and A1298C polymorphisms was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
  • A case-control study design was employed, comparing 224 PMOD cases with 485 age-matched controls.
  • Statistical analyses included assessing genotype and haplotype associations with PMOD risk.

Main Results:

  • Carriage of the T allele for the MTHFR C677T polymorphism was significantly associated with a reduced risk of PMODs (OR=0.62, 95% CI=0.44-0.86).
  • Haplotype analysis revealed that the 677T/1298A haplotype also conferred a decreased risk of PMODs (OR=0.56, 95% CI=0.40-0.80).
  • No significant interactions were found between MTHFR polymorphisms and common lifestyle factors.

Conclusions:

  • The MTHFR C677T genotype (T-allele carriers) and the 677T/1298A haplotype may offer a protective effect against potentially malignant oral disorders.
  • Further validation with larger sample sizes is warranted to confirm these findings.
  • These genetic insights could contribute to future strategies for PMOD risk stratification.
Keywords:
Methylenetetrahydrofolate reductaseTaiwangenetic polymorphismpotentially malignant oral disorders

More Related Videos

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

2.3K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K

Related Concept Videos

Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.5K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.4K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K