Related Experiment Video
Updated: Feb 8, 2026
03:45
Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
3.3K
Dental stem cell and dental tissue regeneration
Qiming Zhai1, Zhiwei Dong2, Wei Wang3
1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Frontiers of Medicine
|July 5, 2018
Summary
Stem cell therapy offers promising avenues for tooth regeneration, utilizing various dental stem cell types like DPSCs and PDLSCs. This review explores strategies for regenerating dental tissues to aid future clinical applications.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Dental Research
Background:
- Teeth are complex organs crucial for mastication, articulation, and aesthetics.
- Tooth regeneration research is challenging due to the intricate nature of dental tissues.
- Recent advancements in tissue engineering have spurred new approaches to tooth regeneration.
Purpose of the Study:
- To review stem cell types isolated from dental tissues.
- To outline stem cell therapy strategies for tooth regeneration.
- To provide a theoretical basis for clinical tooth regeneration treatments.
Main Methods:
- Literature review of stem cell isolation from dental tissues.
- Analysis of stem cell characteristics and regenerative potential.
- Synthesis of current stem cell therapy strategies in tooth regeneration.
Main Results:
- Several dental stem cell populations have been identified, including dental pulp stem cells (DPSCs), stem cells from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs).
- These stem cells demonstrate the capacity to regenerate various tooth tissues.
- Various therapeutic strategies utilizing these cells are being explored.
Conclusions:
- Dental stem cells hold significant potential for tooth regeneration.
- Further research into stem cell therapy strategies is essential for clinical translation.
- This review provides a foundational understanding for advancing regenerative dentistry.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
01:23Tissue Renewal without Stem Cells
2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
2.1K
01:15Neurogenesis and Regeneration of Nervous Tissue
1.7K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.7K
01:33Adult Stem Cells
33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
02:01Plant Cells and Tissues
65.8K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.8K
00:58Embryonic Stem Cells
32.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.5K