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Updated: Feb 8, 2026

In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal
Published on: January 14, 2018
Multicolor Tracking of Molecular Motors at Nanometer Resolution
Sara M Wichner1, Ahmet Yildiz2,3
1Department of Chemistry, University of California, Berkeley, CA, USA.
Abstract:
Molecular motors move processively along cytoskeletal filaments through stepping of their catalytic head domains. Observation of the stepping movement of the heads reveals the mechanism of motor processivity and how they coordinate the cycles of the catalytic heads during processive motility. This chapter will discuss recent developments in simultaneous observation of the stepping motions of the two heads using multicolor single particle tracking microscopy.
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