[Association of vitamin D level with asthma control and pulmonary function in asthmatic children aged 4-12 years]

Area of Science:

• Pediatric Pulmonology
• Nutritional Immunology
• Clinical Medicine

Background:

• Asthma is a common chronic respiratory disease in children.
• Vitamin D deficiency is prevalent and may influence immune responses.
• The relationship between vitamin D status and asthma control in pediatric populations requires further investigation.

Purpose of the Study:

• To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and asthma control.
• To examine the correlation of vitamin D status with pulmonary function in children with asthma.

Main Methods:

• A study involving 150 children with asthma and 55 healthy controls.
• Serum 25(OH)D levels were measured using chemiluminescence microparticle immunoassay.
• Asthma control was assessed, and pulmonary function tests were performed.

Main Results:

• Children with asthma exhibited significantly lower serum 25(OH)D levels compared to healthy controls.
• Higher asthma control rates were observed in children with normal vitamin D levels, followed by those with insufficiency and deficiency.
• No significant differences in pulmonary function were found among the different vitamin D status groups.

Conclusions:

• Asthmatic children generally have lower serum 25(OH)D levels than their healthy peers.
• Serum 25(OH)D levels are associated with asthma control status in children.
• Vitamin D status does not appear to be significantly associated with pulmonary function in children with asthma.