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Current Molecular-Targeted Therapies in NSCLC and Their Mechanism of Resistance

Zachary Schrank1, Gagan Chhabra2, Leo Lin3

  • 1Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA. zacharyschrank15@augustana.edu.

Cancers
|July 6, 2018
PubMed

Insights

Conventional lung cancer treatments cause side effects. Molecularly-targeted therapies show promise but face acquired resistance, necessitating research into biomarkers like EGFR, ALK, and BRAF to overcome treatment challenges.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Conventional lung cancer treatments (surgery, radiation, chemotherapy) have significant side effects.
  • Molecularly-targeted therapies offer an alternative by targeting specific cancer biomarkers.
  • Acquired resistance to targeted therapies is a major clinical hurdle in lung cancer treatment.

Purpose of the Study:

  • To review current lung cancer biomarkers.
  • To explore mechanisms of acquired drug resistance.
  • To inform the development of novel lung cancer therapies.

Main Methods:

  • Literature review of targeted therapies and resistance mechanisms.
  • Analysis of key lung cancer biomarkers including EGFR, ALK, and BRAF.
  • Discussion of signaling pathways involved in acquired resistance.

Main Results:

  • Targeted therapies can lead to initial responses but are often followed by acquired resistance.
  • Mutations and pathway activation are key drivers of resistance.
  • Biomarkers such as EGFR, ALK, and BRAF are crucial in understanding and overcoming resistance.

Conclusions:

  • Understanding acquired resistance mechanisms is vital for improving lung cancer patient outcomes.
  • Further research into novel therapies targeting resistance pathways is needed.
  • Biomarker-driven strategies are essential for effective lung cancer treatment.
Keywords:
TKIinhibitorlung cancermolecularly-targeted therapiesresistance

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