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Increased bioavailability of curcumin using a novel dispersion technology system (LipiSperse®)
D Briskey1,2, A Sax3, A R Mallard4,5
1School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia. d.briskey@uq.edu.au.
European Journal of Nutrition
|July 6, 2018
Summary
LipiSperse® significantly enhances curcumin bioavailability, delivering higher plasma concentrations compared to standard curcumin. This novel delivery system is safe for human use and improves curcumin absorption.
Area of Science:
- Pharmacology
- Nutraceutical Science
- Bioavailability Research
Background:
- Curcumin exhibits therapeutic potential against inflammatory and oxidative stress-related degenerative conditions.
- Poor oral bioavailability limits effective therapeutic dosing of curcumin.
- LipiSperse® is a dispersion technology designed to improve the bioavailability of hydrophobic compounds.
Purpose of the Study:
- To evaluate the pharmacokinetics of curcumin when formulated with the LipiSperse® delivery system.
- To compare the bioavailability of curcumin with and without LipiSperse® in healthy human volunteers.
Main Methods:
- A randomized, double-blind, placebo-controlled study involving 18 healthy participants.
- Single equivalent dose administration of 750 mg curcuminoids (with or without LipiSperse®).
- Plasma curcuminoid concentrations measured over a 24-hour period.
Main Results:
- Curcumin formulated with LipiSperse® resulted in significantly higher plasma curcuminoid concentrations compared to standard curcumin.
- The crossover trial showed plasma concentrations of 807 ng/mL for LipiSperse® curcumin versus 318 ng/mL for standard curcumin.
- The parallel trial also demonstrated superior plasma levels for the LipiSperse® formulation.
Conclusions:
- The LipiSperse® delivery system is safe for human consumption.
- LipiSperse® significantly enhances the bioavailability of curcumin compared to standard extracts.
- This technology offers a promising approach for improving curcumin's therapeutic efficacy.
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