Related Experiment Video
Updated: Feb 8, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
847
Skin flap squamous cell carcinoma developed after urethroplasty
Danilo Abate1, Giuseppe Giusti, Nicola Caria
1Clinica Urologica, Università degli Studi di Cagliari, Ospedale SS. Trinità, Cagliari. nicolacaria1@gmail.com.
Summary
Urethral carcinoma is a rare but severe complication after Orandi penile skin flap urethroplasty. Long-term urological follow-up is crucial for early detection and management of this condition.
Area of Science:
- Urology
- Oncology
Background:
- Urethroplasty using penile skin flaps is a reconstructive surgical technique.
- Orandi penile skin flap is one such method used in urethroplasty.
Observation:
- A patient developed urethral epidermoid carcinoma on an Orandi penile skin flap 15 years post-urethroplasty.
- Treatment involved partial penectomy, chemotherapy (cisplatin, 5-fluorouracil), and salvage total penectomy with orchiectomy.
Findings:
- Despite aggressive treatment, the patient succumbed to the disease three months after the final surgery.
- Urethral carcinoma arising from a skin flap is a rare but aggressive complication.
Implications:
- This case highlights the potential for late-onset malignancy following urethroplasty with skin flaps.
- Long-term urological surveillance is recommended for patients who have undergone such procedures to monitor for rare complications like urethral carcinoma.
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