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Updated: Feb 8, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Driven Epoxyacylation and Hydroacylation of Olefins Using Methylene Blue/Persulfate System in Water
Gabriela F P de Souza1, Juliano A Bonacin2, Airton G Salles1
1Department of Organic Chemistry, Institute of Chemistry , University of Campinas , P.O. Box 6154, Campinas , São Paulo , 13084-862 , Brazil.
Abstract:
A visible-light-driven strategy for hydroacylation and epoxyacylation of olefins in water using methylene blue as photoredox catalyst and persulfate as oxidant is reported. In this unprecedented unified approach, two different transformations are accomplished using only one set of reagents. The method has a broad scope spanning a range of aromatic and aliphatic aldehydes as well as conjugated and nonconjugated olefins to deliver ketones and epoxyketones from abundant and inexpensive chemical feedstocks.
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