Structure of the Epstein-Barr virus nuclear antigen as probed with monoclonal antibodies

Five hybridoma cell lines secreting antibodies directed against an Epstein-Barr virus (EBV) nuclear antigen (BamHI K antigen) have been isolated. All five antibodies detect this antigen in a variety of EBV-positive lymphoblastoid cell lines. The reaction of these antibodies with several mutant forms of this protein has allowed the antibody binding site(s) to be predicted.