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Radiation induced secondary malignancies: a review article
Chinna Babu Dracham1, Abhash Shankar1, Renu Madan1
1Department of Radiotherapy and Oncology, PGIMER, Chandigarh, India.
Radiation Oncology Journal
|July 10, 2018
Summary
Radiation-induced second malignancies (RISM) are a growing concern for cancer survivors. This review discusses RISM pathogenesis, contributing factors, and strategies for screening and prevention.
Area of Science:
- Oncology
- Radiation Oncology
- Cancer Research
Background:
- Radiation-induced second malignancies (RISM) are a significant late complication of radiation therapy.
- RISM impacts treatment decisions and survivorship care.
- The incidence of RISM is a growing concern due to increased cancer survival rates.
Purpose of the Study:
- To review the pathogenesis of RISM.
- To identify factors contributing to RISM development.
- To discuss current screening and prevention strategies for RISM.
Main Methods:
- Comprehensive literature search using PubMed and Google Scholar.
- Keywords included 'radiation induced malignancies', 'second malignancies', and 'chemotherapy induced malignancies'.
- Relevant articles were identified through reference lists.
Main Results:
- Multiple factors influence RISM, including age, radiation dose/volume, organ type, technique, and patient history.
- The exact mechanism of RISM remains unclear.
- Ongoing efforts focus on preventing and reducing RISM incidence.
Conclusions:
- Understanding RISM pathogenesis and contributing factors is crucial.
- Effective screening and prevention strategies are needed to mitigate RISM risks in cancer survivors.
- Further research into RISM mechanisms is warranted.
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