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Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications
Published on: July 14, 2017
Preparation of porous zinc ferrite/carbon as a magnetic-assisted dispersive miniaturized solid phase extraction
Shujun Xia1, Zhixiong Cai1, Jing Dong1
1Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Abstract:
In this study, porous ZnFe2O4/carbon, derived from Zn-Fe zeolitic imidazolate framework (Zn-Fe-ZIF), was employed as a novel sorbent for magnetic-assisted dispersive miniaturized solid phase extraction (M-DμSPE). The Zn-Fe-ZIF derived magnetic porous ZnFe2O4/carbon was easily prepared using a one-pot solvothermal method, and its morphology, structure and magnetic characteristics were evaluated via scanning electron microscopy, powder X-ray diffraction, Raman spectroscopy and vibrating sample magnetometry. The extraction ability of ZnFe2O4/carbon is evaluated by different kinds of compounds including organochlorine pesticides, pyrethroid insecticides, aldehydes, nerolidol, benzoic acid and sorbic acid. A M-DμSPE method was developed for the analysis of organochlorine pesticides. Several parameters affecting the extraction efficiency were systematically investigated. The calibration curves ranged from 0.05 to 100 ng g-1 and the limits of detection were 0.005-0.3 ng g-1. The intra-day and inter-day relative standard deviations were lower than 2.3 and 5.2%. The recoveries of spiked organochlorine pesticides were in the range of 86.1-109.4%.
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