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A practical guide for using lithium halocarbenoids in homologation reactions
Serena Monticelli1, Marta Rui1, Laura Castoldi1
1Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.
Monatshefte Fur Chemie
|July 10, 2018
Summary
Lithium halocarbenoids are key reagents for carbon chain extension. This study details practical methods to overcome their rapid alpha-elimination, enabling effective use in homologation reactions.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Lithium halocarbenoids are valuable synthetic intermediates.
- Their utility is often limited by rapid alpha-elimination reactions.
Purpose of the Study:
- To provide practical strategies for employing lithium halocarbenoids in homologation.
- To overcome the limitations posed by alpha-elimination.
Main Methods:
- Investigated practical considerations for using lithium halocarbenoids.
- Applied these reagents in the homologation of carbon electrophiles.
Main Results:
- Developed effective methods for utilizing lithium halocarbenoids.
- Successfully achieved homologation of selected carbon electrophiles.
Conclusions:
- The presented strategies enable effective application of lithium halocarbenoids.
- Overcoming alpha-elimination broadens their synthetic utility in organic synthesis.
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