Related Experiment Video
Updated: Feb 8, 2026

Establishing a Diaphyseal Femur Fracture Model in Mice
Published on: December 9, 2022
Massive heterotopic ossification after distal femur fracture
Gokhan Ozkocak1, Guzin Cakir Kandemirli2, Suheda Ozcakir3
11 MD, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Uludag University, Turkey.
Abstract:
Introduction Heterotopic ossification is the formation of lamellar bone in periarticular soft tissue that can be seen in paralysed patients or following trauma. It can cause significant burden to already debilitated patients. Case presentation A 12-year-old boy with paraplegia due to neuromyelitis optica presented with progressive right knee pain and swelling. There was no history of trauma to the knee. Anteroposterior radiograph of femur at the initial presentation showed a supracondylar femur fracture for which casting was performed. Six weeks later, when casting was removed, swelling along with increased rubor in distal thigh region was noted. Radiography of the right femur revealed an unhealed distal femur fracture along with massive ossification extending from lesser trochanter to fracture line along the soft tissue around the femoral shaft. Conclusion This case presented the clinical and imaging findings of a giant heterotopic ossification in the thigh region following an extra-articular fracture.
Related Concept Videos
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Bone Formation by Endochondral Ossification
Bones of the Lower Limb: Femur and Patella
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons
Biological Effects of Radiation

