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Dose-response relationship between thyroid stimulating hormone and hypertension risk in euthyroid individuals
Weiwei He1, Sheli Li1, Bin Wang2
1Department of Endocrinology, Affiliated Hospital of Yan'an Medical University, Yan'an, Shaanxi.
Journal of Hypertension
|July 10, 2018
Summary
Higher normal thyroid stimulating hormone (TSH) levels are linked to an increased risk of hypertension in euthyroid individuals. This dose-response relationship suggests monitoring TSH is crucial for cardiovascular health.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Public Health
Background:
- Thyroid dysfunction adversely affects the cardiovascular system.
- The link between thyroid stimulating hormone (TSH) levels and hypertension risk in euthyroid individuals remains unclear.
Purpose of the Study:
- To investigate the association between TSH levels and hypertension risk in euthyroid individuals.
- To assess the dose-response relationship between TSH and hypertension using meta-analysis.
Main Methods:
- A population-based, cross-sectional study involving 2289 euthyroid individuals.
- Logistic regression analysis to evaluate TSH and hypertension risk.
- Dose-response meta-analysis of relevant cohort and cross-sectional studies.
Main Results:
- Elevated serum TSH within the upper normal range correlated with a higher hypertension risk (OR=1.29, P=0.023).
- This association remained significant after adjusting for confounders (OR=1.32, P=0.041).
- Meta-analysis confirmed a dose-response relationship, with each 1 mIU/l TSH increase associated with higher hypertension risk (OR=1.09, P<0.001) and elevated SBP/DBP.
Conclusions:
- Strong evidence supports a dose-response relationship between serum TSH and hypertension risk in euthyroid individuals.
- Euthyroid individuals with higher normal TSH levels face a greater risk of developing hypertension.
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