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Related Experiment Videos

Cellular retinoid binding proteins.

J Sundelin, U Eriksson, H Melhus

    Chemistry and Physics of Lipids
    |August 30, 1985
    PubMed
    Summary
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    Cellular retinol-binding protein (CRBP) and cellular retinoic acid binding protein (CRABP) share similar traits and are highly conserved. These proteins likely transport retinol and retinoic acid within cells, respectively.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Background:

    • Cellular retinol-binding protein (CRBP) and cellular retinoic acid binding protein (CRABP) are key proteins involved in retinoid metabolism.
    • These proteins exhibit similar physicochemical properties, suggesting related functions.

    Purpose of the Study:

    • To investigate the structural and evolutionary conservation of CRBP and CRABP.
    • To elucidate the potential roles of CRBP and CRABP as cellular transport proteins for retinol and retinoic acid.

    Main Methods:

    • Amino acid sequence analysis of rat CRBP and bovine CRABP.
    • Deduction of human CRBP amino acid sequence from cDNA.
    • Comparison of sequence identities and evolutionary conservation.

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    Main Results:

    • Rat CRBP and bovine CRABP share 40% amino acid sequence identity and are highly conserved evolutionarily.
    • Human CRBP shows 96% sequence identity to rat CRBP.
    • CRBP and CRABP belong to a protein family likely binding hydrophobic ligands and interacting with membranes.

    Conclusions:

    • CRBP and CRABP are likely cellular transport proteins for retinol and retinoic acid, respectively.
    • Their conserved structure and tissue distribution support their roles in retinoid transport and cellular function.