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Updated: Feb 8, 2026

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
New Insights about How to Make an Intervention in Children and Adolescents with Metabolic Syndrome: Diet, Exercise
Enrique Albert Pérez1, Victoria Mateu Olivares2, Rosa María Martínez-Espinosa3,4
1Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain. ejalbertperez@gmail.com.
Objective:
To record which interventions produce the greatest variations in body composition in patients ≤19 years old with metabolic syndrome (MS).
Method:
search dates between 2005 and 2017 in peer reviewed journals, following the PRISMA method (Preferred Reporting Items for Systematic reviews and Meta-Analyses). The selection criteria were: diagnostic for MS or at least a criterion for diagnosis; randomized clinical trials, ≤19 years of age; intervention programs that use diet and/or exercise as a tool (interventions showing an interest in body composition).
Results:
1781 clinical trials were identified under these criteria but only 0.51% were included. The most frequent characteristics of the selected clinical trials were that they used multidisciplinary interventions and were carried out in America. The most utilized parameters were BMI (body mass index) in kg/m² and BW (body weight) in kg.
Conclusions:
Most of the clinical trials included had been diagnosed through at least 2 diagnostic criteria for MS. Multidisciplinary interventions obtained greater changes in body composition in patients with MS. This change was especially prevalent in the combinations of dietary interventions and physical exercise. It is proposed to follow the guidelines proposed for patients who are overweight, obese, or have diabetes type 2, and extrapolate these strategies as recommendations for future clinical trials designed for patients with MS.
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