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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Pollen-Structured Gold Nanoclusters for X-ray Induced Photodynamic Therapy.

Lih Shin Tew1,2, Meng-Ting Cai3, Leu-Wei Lo4

  • 1Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas 13200, Malaysia. tls16_ipg005@student.usm.my.

Materials (Basel, Switzerland)
|July 11, 2018
PubMed
Summary
This summary is machine-generated.

Pollen-structured gold clusters enhance X-ray-induced photodynamic therapy (PDT) for deep-tissue cancer treatment. These clusters effectively generate reactive oxygen species (ROS) to induce cancer cell death, improving radiotherapy outcomes.

Keywords:
mesoporous silicaphotodynamic therapypollen-structured gold clustersreactive oxygen species

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Photodynamic therapy (PDT) is limited by light penetration depth for treating deep-seated tumors.
  • Conventional PDT relies on light activation, restricting its application in deeper tissues.
  • There is a need for innovative approaches to enhance PDT efficacy in challenging cancer sites.

Purpose of the Study:

  • To design and synthesize pollen-structured gold clusters (PSGCs) for X-ray-induced PDT.
  • To evaluate the reactive oxygen species (ROS) generation capacity of PSGCs under X-ray irradiation.
  • To assess the efficacy of PSGC-mediated PDT in breast cancer cells for potential radiotherapy enhancement.

Main Methods:

  • Synthesis of pollen-structured gold clusters (PSGCs).
  • X-ray irradiation of PSGCs followed by quantification of generated ROS using dihydroethidium (DHE) assay.
  • Evaluation of cellular PDT efficacy through immunofluorescence staining for γ-H2AX and comet assay in breast cancer cells.

Main Results:

  • PSGCs demonstrated a significant capacity for ROS generation upon X-ray irradiation.
  • PSGCs exhibited remarkable PDT efficacy in treating breast cancer cells.
  • The study confirmed the potential of PSGCs in enhancing radiotherapy for deep-tissue cancers.

Conclusions:

  • PSGCs are effective agents for X-ray-induced PDT, overcoming light penetration limitations.
  • The high ROS-generating ability and cellular efficacy of PSGCs show promise for clinical applications in deep-tissue cancer treatment.
  • PSGCs represent a viable strategy for improving radiotherapy outcomes in oncology.