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In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

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Mouse Models of COPD.

Karina A Serban¹, Irina Petrache²

¹Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA. serbank@njhealth.org.

Methods in Molecular Biology (Clifton, N.J.)

|July 11, 2018

Summary

This summary is machine-generated.

This chapter details animal models, including elastase and cigarette smoke, for studying chronic obstructive pulmonary disease (COPD) pathogenesis and emphysema. It also covers methods for assessing e-cigarette vapor effects on lung health.

Keywords:

COPD Cigarette smoke E-cigarette Elastase Emphysema Mean linear intercept Mouse

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Area of Science:

Pulmonary Medicine
Toxicology
Animal Models

Background:

Emphysema and COPD pathogenesis are studied using animal models.
Chronic cigarette smoke and elastase exposure induce emphysema-like changes.
Emerging e-cigarette use necessitates understanding its lung health impact.

Purpose of the Study:

To describe the rationale and protocols for using elastase and cigarette smoke models in COPD research.
To provide methods for investigating the effects of e-cigarette vapors on lung health.
To outline tools for assessing lung morphologic and functional changes in emphysema models.

Main Methods:

Utilizing elastase-induced and chronic cigarette smoke exposure in animal models.
Implementing protocols for COPD pathogenesis studies.
Developing approaches to assess e-cigarette vapor effects.
Employing methods to evaluate lung morphologic and functional alterations.

Main Results:

Established protocols for common emphysema animal models.
Included methods for e-cigarette vapor assessment.
Provided tools for analyzing lung changes in emphysema models.

Conclusions:

Elastase and cigarette smoke models are crucial for studying COPD.
E-cigarette vapor research methods are now available.
Comprehensive assessment of lung changes in emphysema models is facilitated.