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Updated: Feb 8, 2026
08:25
Transverse Aortic Constriction in Mice
Published on: April 21, 2010
69.2K
Conventional Method of Transverse Aortic Constriction in Mice
Jimeen Yoo1, Vadim Chepurko1, Roger J Hajjar1
1Department of Cardiology/Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Methods in Molecular Biology (Clifton, N.J.)
|July 11, 2018
Summary
Transverse aortic constriction in mice models left ventricular pressure overload, progressing from compensated hypertrophy to heart failure. This reproducible surgical method aids in studying cardiac disease and evaluating therapeutic interventions.
Area of Science:
- Cardiovascular Research
- Surgical Models
- Cardiac Physiology
Background:
- Transverse aortic constriction (TAC) is a key mouse model for studying left ventricular pressure overload.
- It mimics the progression from cardiac hypertrophy to heart failure.
- The model is characterized by an initial compensated hypertrophy followed by maladaptive remodeling.
Purpose of the Study:
- To provide a simplified and practical methodology for performing transverse aortic constriction in mice.
- To facilitate consistent replication of the model for cardiac research.
- To aid in the evaluation of therapeutic interventions for heart failure.
Main Methods:
- Surgical induction of transverse aortic constriction in mice.
- Monitoring of cardiac hypertrophy and remodeling progression.
- Assessment of left ventricular pressure overload.
Main Results:
- TAC consistently induces left ventricular pressure overload.
- The model reliably replicates the transition from compensated hypertrophy to heart failure.
- Low surgical mortality and replicability are key advantages.
Conclusions:
- Transverse aortic constriction is a valuable and reproducible surgical model for cardiac research.
- It effectively simulates pressure overload-induced heart failure progression.
- This methodology offers a practical approach for studying cardiac disease and therapeutic efficacy.
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