Related Experiment Video
Updated: Feb 8, 2026

Designing a Bio-responsive Robot from DNA Origami
Published on: July 8, 2013
Self-Assembly of Large DNA Origami with Custom-Designed Scaffolds
Xiaoxing Chen1, Qian Wang1, Jin Peng1
1Department of Biomedical Engineering, College of Engineering and Applied Sciences , Nanjing University , Nanjing , Jiangsu 210093 , P. R. China.
Abstract:
As a milestone in DNA self-assembly, DNA origami has demonstrated powerful applications in many fields. However, the scarce availability of long single-stranded DNA (ssDNA) limits the size and sequences of DNA origami nanostructures, which in turn impedes the further development. In this study, we present a robust strategy to produce long circular ssDNA scaffold strands with custom-tailored lengths and sequences. These ssDNA products were then used as scaffolds for constructing various DNA origami nanostructures. This scalable method produces ssDNA at low cost with high purity and high yield, which can enable production of custom-designed DNA origami for various applications.
Related Concept Videos
Group Design
From DNA to Protein
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Factorial Design
Design Example: Designing a Residential Plumbing System
Design Example: Designing Water Slide
Bernoulli's principle determines the water's velocity along the slide....

