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Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma

Hongyan Zhang1, Yuan Wang2, Jibin Lu3

  • 1Department of Clinical Genetics, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China; Department of Thoracic surgery, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 11, 2018
PubMed

Insights

Long noncoding RNA LINC00222 acts as a tumor suppressor in lung adenocarcinoma. Its downregulation promotes cancer cell proliferation and metastasis, suggesting it as a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • Long noncoding RNAs (lncRNAs) are critical regulators of cellular processes.
  • Dysregulation of lncRNAs is implicated in various cancers, including lung adenocarcinoma.
  • Mechanisms of lncRNA action in lung adenocarcinoma are not fully understood.

Purpose of the Study:

  • To investigate the role of lncRNA LINC00222 in lung adenocarcinoma.
  • To explore LINC00222 as a potential biomarker and therapeutic target.

Main Methods:

  • Quantitative analysis of LINC00222 expression in 76 lung adenocarcinoma tissues and paired normal tissues.
  • In vitro experiments involving enforced expression of LINC00222 in lung adenocarcinoma cells.
  • Assessment of cell proliferation, migration, invasion, and apoptosis.
  • Analysis of glycogen synthase kinase-3β (GSK3β) activity and Wnt signaling pathway modulation.

Main Results:

  • LINC00222 was found to be significantly downregulated in lung adenocarcinoma tissues.
  • Enforced LINC00222 expression inhibited proliferation, migration, and invasion of lung adenocarcinoma cells.
  • Overexpression of LINC00222 induced apoptosis in cancer cells.
  • LINC00222 overexpression enhanced GSK3β activity, impacting the Wnt signaling pathway.

Conclusions:

  • LINC00222 functions as a tumor suppressor in lung adenocarcinoma.
  • LINC00222 holds potential as a prognostic biomarker for lung adenocarcinoma.
  • LINC00222 represents a promising therapeutic target for lung adenocarcinoma treatment.
Keywords:
GSK3βLINC00222Lung cancerWnt signaling pathway

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