Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

Protein Complex Assembly

Protein Complex Assembly

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Self-Powered Dressing Based on a Zn-Mo Galvanic Cell for Accelerated Wound Repair.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Deep learning-enabled versatile shape perception for soft robots via single-ended multimode fiber.

Science advances·2026

Same author

Lithium Attenuates Brain Injury and Inflammation in Neonatal Rats with Germinal Matrix Hemorrhage.

Current neuropharmacology·2026

Same author

Correction: Case Report: Novel mutations in two patients with <i>MED13L</i>-related intellectual disability highlighting the importance of genetic counseling.

Frontiers in genetics·2026

Same author

Stable rat models in constipation with depression and anxiety: evaluation and validation.

Frontiers in behavioral neuroscience·2026

Same author

The Effect of Pore Size on Cell Ingrowth in PLLA/HA Scaffolds for Bone Tissue Engineering.

Tissue engineering. Part A·2026

Same journal

circ2DGNN: circRNA-Disease Association Prediction via Transformer-Based Graph Neural Network.

IEEE/ACM transactions on computational biology and bioinformatics·2024

Same journal

Hierarchical Hypergraph Learning in Association- Weighted Heterogeneous Network for miRNA- Disease Association Identification.

IEEE/ACM transactions on computational biology and bioinformatics·2024

Same journal

Discriminative Domain Adaption Network for Simultaneously Removing Batch Effects and Annotating Cell Types in Single-Cell RNA-Seq.

IEEE/ACM transactions on computational biology and bioinformatics·2024

Same journal

MLW-BFECF: A Multi-Weighted Dynamic Cascade Forest Based on Bilinear Feature Extraction for Predicting the Stage of Kidney Renal Clear Cell Carcinoma on Multi-Modal Gene Data.

IEEE/ACM transactions on computational biology and bioinformatics·2024

Same journal

An End-to-End Knowledge Graph Fused Graph Neural Network for Accurate Protein-Protein Interactions Prediction.

IEEE/ACM transactions on computational biology and bioinformatics·2024

Same journal

Generative Biomedical Event Extraction With Constrained Decoding Strategy.

IEEE/ACM transactions on computational biology and bioinformatics·2024

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 8, 2026

Identification of Post-translational Modifications of Plant Protein Complexes

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

Measuring Boundedness for Protein Complex Identification in PPI Networks.

Tiantian He, Keith C C Chan

IEEE/ACM Transactions on Computational Biology and Bioinformatics

|July 12, 2018

Summary

This summary is machine-generated.

This study introduces TBPCI, a new method for identifying protein complexes in protein-protein interaction networks. TBPCI uses a novel "degree of boundedness" measure, improving protein complex identification accuracy.

More Related Videos

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Identification of protein complexes with quantitative proteomics in S. cerevisiae

Identification of protein complexes with quantitative proteomics in S. cerevisiae

Published on: March 4, 2009

Related Experiment Videos

Last Updated: Feb 8, 2026

Identification of Post-translational Modifications of Plant Protein Complexes

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Identification of protein complexes with quantitative proteomics in S. cerevisiae

Identification of protein complexes with quantitative proteomics in S. cerevisiae

Published on: March 4, 2009

Area of Science:

Bioinformatics
Computational Biology
Systems Biology

Background:

Protein-protein interaction (PPI) networks are crucial for understanding cellular functions.
Identifying protein complexes within PPI networks is a fundamental challenge in systems biology.
Current methods often focus on identifying dense regions, which may not fully capture complex formation.

Purpose of the Study:

To present a novel approach, TBPCI, for identifying protein complexes.
To move beyond dense region identification by introducing a measure of boundedness.
To enhance the accuracy of protein complex detection in PPI networks.

Main Methods:

Developed TBPCI, a method based on a measure of boundedness.
Defined boundedness using a Jaccard Index-based connectedness and a Gene Ontology (GO) attribute association measure.
Employed a Breadth-First-Search (BFS) algorithm to group proteins into complexes based on calculated boundedness.

Main Results:

TBPCI effectively identifies protein complexes by assessing the aggregated degree of boundedness between protein pairs.
Experimental validation on real datasets demonstrates the efficacy of the TBPCI approach.
The method shows improved performance compared to traditional dense-region identification strategies.

Conclusions:

TBPCI offers a robust and effective strategy for protein complex identification in PPI networks.
The novel measure of boundedness provides a more nuanced understanding of protein complex formation.
This approach has significant implications for advancing research in molecular and systems biology.