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What is the state of hybrid coronary revascularization in 2018?
Bobby Yanagawa1, Kathryn Hong1, Asim Cheema2
1Divisions of Cardiac Surgery.
Insights
Hybrid coronary revascularization (HCR) offers a combined approach to treating heart disease. Recent findings show no significant differences in major cardiovascular outcomes compared to traditional methods, with ongoing trials to further clarify its role.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Minimally Invasive Surgery
Background:
- Hybrid coronary revascularization (HCR) integrates minimally invasive surgical bypass with percutaneous coronary intervention (PCI).
- This approach aims to combine the benefits of surgical and interventional strategies for coronary artery disease.
Purpose of the Study:
- To provide an update on hybrid coronary revascularization (HCR) developments over the past 12 months.
- To review recent findings and ongoing trials evaluating HCR outcomes.
Main Methods:
- Review of single-center observational series comparing HCR with coronary artery bypass graft (CABG) and PCI.
- Analysis of the 5-year results from the first randomized study comparing HCR to CABG.
- Examination of a prospective observational study comparing HCR with multivessel PCI.
- Highlighting the ongoing Hybrid Coronary Revascularization Trial, a multicenter randomized controlled trial.
Main Results:
- Most observational studies show no significant differences in major cardiovascular outcomes between HCR and CABG or HCR and PCI.
- The first randomized trial reported no difference in mortality, myocardial infarction, or repeat revascularization at 5 years between HCR and CABG.
- A large observational study found no difference in risk-adjusted major adverse cardiovascular events at 12 months between HCR and multivessel PCI.
Conclusions:
- HCR is a potentially valuable option for selected patients with complex coronary artery disease, particularly when performed at experienced centers.
- Ongoing large-scale trials are expected to provide further insights into the clinical role and optimal patient selection for HCR.
- The results suggest HCR may offer comparable outcomes to traditional revascularization methods, warranting further investigation.
Purpose Of Review:
Hybrid coronary revascularization (HCR) combines minimally invasive surgical bypass with percutaneous coronary intervention (PCI) using drug-eluting stents, the goal being to leverage the strengths of each approach. Here we provide an update on HCR from the past 12 months.
Recent Findings:
HCR represents a minority of surgical revascularization cases from a small number of highly experienced surgical centers. Most single-center observational series show no differences in major cardiovascular outcomes comparing HCR and coronary artery bypass graft (CABG) or HCR and PCI. The 5-year results of the first randomized study comparing HCR to CABG reported no difference in all-cause mortality, myocardial infarction, and repeat revascularization. Comparing HCR with multivessel PCI, a large, prospective observational study reported no difference in risk-adjusted major adverse cardiovascular events at 12 months. The Hybrid Coronary Revascularization Trial is an international, multicenter, randomized controlled trial to compare HCR versus PCI for patients with proximal left anterior descending disease or left main disease. This trial is currently recruiting patients.
Summary:
HCR is a potentially attractive alternative to both surgical revascularization and multivessel PCI when performed in experienced centers for highly selected patients. The results of a large, multicenter, prospective trial will provide greater clarity on the clinical role and optimal coronary anatomy for this third revascularization option.
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