Related Experiment Video

Updated: Feb 7, 2026

Intraoperative Ultrasound in Spinal Surgery
05:53

Intraoperative Ultrasound in Spinal Surgery

Published on: August 17, 2022

5.4K

Antiscarring effect of intraoperative bevacizumab in experimental glaucoma filtration surgery

Christiana Rebello Hilgert1,2, Alvaro Haverroth Hilgert2, Alexandre Nakao Odashiro3,4

  • 1Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Arquivos Brasileiros De Oftalmologia
|July 12, 2018
PubMed
Abstract

Insights

Bevacizumab and mitomycin C combination therapy reduced intraocular pressure and scarring after glaucoma surgery. However, bevacizumab alone more effectively inhibited VEGF expression compared to the combination.

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Research

Background:

  • Glaucoma filtration surgery aims to reduce intraocular pressure.
  • Scarring is a common complication that can lead to surgical failure.
  • Anti-VEGF agents are explored to modulate the healing process.

Purpose of the Study:

  • To evaluate the impact of bevacizumab and mitomycin C, alone and combined, on intraocular pressure and scarring post-glaucoma surgery in rabbits.
  • To assess the effect of these agents on vascular endothelial growth factor (VEGF) expression.

Main Methods:

  • Modified glaucoma filtration surgery was performed on rabbits.
  • Animals received subconjunctival bevacizumab, mitomycin C plus bevacizumab, or mitomycin C.
  • Intraocular pressure, fibrosis, and VEGF expression were measured post-surgery.

Main Results:

  • The combination of bevacizumab and mitomycin C, and mitomycin C alone, resulted in lower intraocular pressure compared to bevacizumab alone.
  • Fibrosis levels were similar across groups, with bevacizumab alone showing the highest level.
  • Vascular endothelial growth factor (VEGF) expression was significantly lower in the bevacizumab-only group.

Conclusions:

  • Combining bevacizumab with mitomycin C did not offer additional benefits in reducing intraocular pressure or fibrosis compared to mitomycin C alone.
  • Bevacizumab monotherapy demonstrated superior inhibition of VEGF expression.
  • Further research is needed to optimize anti-VEGF and anti-fibrotic strategies in glaucoma surgery.

More Related Videos

Intraoperative Gastroscopy for Tumor Localization in Laparoscopic Surgery for Gastric Adenocarcinoma10:31

Intraoperative Gastroscopy for Tumor Localization in Laparoscopic Surgery for Gastric Adenocarcinoma

Published on: August 9, 2016

13.4K
Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres06:35

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Published on: February 2, 2015

17.9K

Related Concept Videos

Filtration and Urine Formation01:32

Filtration and Urine Formation

The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
53.8K
Glomerular Filtration: Net Filtration Pressure01:26

Glomerular Filtration: Net Filtration Pressure

Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
8.3K
Filtration00:53

Filtration

Filtration is a physical separation process that involves passing a suspension through a porous medium to separate solids from fluids. During filtration, solids collect on the porous medium while liquids, also collectively known as the filtrate, pass through. The filtration medium is selected based on the filtration purpose, quantity, and nature of the precipitate. The general criteria for a suitable filtering medium are that it is inert, mechanically strong, nonabsorbent toward dissolved...
5.2K
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
5.4K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K