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Updated: Feb 7, 2026
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Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
Published on: July 15, 2009
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Daily melatonin administration improves osseointegration in pinealectomized rats.
Letícia Pitol Palin1, Tarik Ocon Braga Polo2, Fábio Roberto de Souza Batista2
1Univ. Estadual Paulista, Faculdade de Odontologia, Departamento de Ciências Básicas, Araçatuba, São Paulo, Brasil.
Journal of Applied Oral Science : Revista FOB
|July 12, 2018
Summary
Pinealectomy in rats delayed bone healing during osseointegration. Daily melatonin supplementation restored this bone repair process, indicating the pineal gland
Area of Science:
- Biomedical Engineering
- Orthopedics
- Endocrinology
Background:
- The pineal gland and its hormone melatonin play roles in various physiological processes.
- Bone healing and osseointegration are critical for the success of dental and orthopedic implants.
- The impact of pinealectomy on peri-implant bone healing remains largely unexplored.
Purpose of the Study:
- To investigate the effects of pinealectomy on bone healing at the bone/implant interface.
- To evaluate the role of melatonin in modulating peri-implant bone healing in pinealectomized rats.
Main Methods:
- Adult male Wistar rats were divided into control, pinealectomized (PNX), and pinealectomized with melatonin (PNXm) groups.
- Titanium implants were placed in the tibias of all rats.
- Immunohistochemistry, micro-computed tomography, and fluorochrome analysis were used to assess bone healing.
Main Results:
- Pinealectomy (PNX) delayed the expression of key bone healing markers (RUNX2, ALP, OP, OC).
- Melatonin supplementation (PNXm) normalized the expression of these markers, similar to the control group.
- Microtomography showed no significant difference in total porosity, but differences in connective density were observed.
- Fluorochrome analysis revealed significant differences in mineralized surface between groups.
Conclusions:
- The absence of the pineal gland negatively impacts peri-implant bone healing and osseointegration.
- Melatonin replacement effectively restores bone healing in pinealectomized rats.
- These findings highlight the pineal gland's role in bone repair and the therapeutic potential of melatonin.
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