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Local Delivery of Genistein in Peri-Implant Defects Enhances Osseointegration in Ovariectomized Rats
Nathália Dantas Duarte1,2, Fábio Roberto de Souza Batista3, Marcelly Braga Gomes4
1Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil. duarte.71@osu.edu.
Calcified Tissue International
|February 17, 2026
Summary
Genistein enhances bone repair by functionalizing biomaterials like bioactive glass and deproteinized bovine bone. This study shows genistein-loaded materials significantly improve peri-implant bone healing in ovariectomized rats.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Dental Implantology
Background:
- Estrogen deficiency, common in osteoporosis, impairs peri-implant healing, necessitating careful dental implant planning.
- Functionalizing biomaterials with soy isoflavones like genistein can improve bone healing potential.
Purpose of the Study:
- To investigate genistein's effect on bioactive glass and deproteinized bovine bone for peri-implant bone repair.
- To evaluate sonochemically functionalized materials in an ovariectomized rat model.
Main Methods:
- Ovariectomized rats received implants with blood clot, bioactive glass (BG), BG+genistein (BG+GEN), deproteinized bovine bone (BO), or BO+genistein (BO+GEN).
- Bone repair was assessed via removal torque, bone marker analysis (RANKL, OPG, OCN, IBSP), and micro-computed tomography (Micro-CT).
Main Results:
- Genistein-functionalized materials (BO+GEN, BG+GEN) significantly increased removal torque and bone volume percentage (BV/TV).
- Bone markers were upregulated, and trabecular separation decreased with genistein treatment.
- BO+GEN demonstrated the highest removal torque and improved bone parameters compared to controls.
Conclusions:
- Genistein potentiates the osteoconductive properties of bioactive glass and deproteinized bovine bone.
- Genistein-functionalized biomaterials enhance peri-implant bone repair in an osteoporosis model.
- This approach holds promise for improving dental implant success in estrogen-deficient patients.
