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Expression and Purification of Virus-like Particles for Vaccination
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Progress toward a group B streptococcal vaccine.

Joon Young Song1, Jae Hyang Lim2, Sangyong Lim3,4

  • 1a Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.

Human Vaccines & Immunotherapeutics
|July 12, 2018
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Summary

Maternal immunization is the most promising strategy against Streptococcus agalactiae (group B Streptococcus) infections in newborns. Vaccine development and immunoassays are advancing to combat GBS disease globally.

Keywords:
Streptococcus agalactiaegroup B Streptococcusmaternal immunizationvaccine

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Area of Science:

  • Microbiology
  • Immunology
  • Vaccinology

Background:

  • Group B Streptococcus (GBS) causes severe invasive disease in neonates, elderly, and immunocompromised individuals.
  • Despite advances, GBS remains a leading cause of neonatal morbidity and mortality, with increasing infections in pregnant women and the elderly.
  • Intrapartum antibiotic prophylaxis (IAP) has limitations, including antimicrobial resistance and late-onset GBS infections.

Purpose of the Study:

  • To provide an overview of the current status of GBS vaccine development.
  • To highlight recent advances in immunoassays for evaluating GBS vaccine clinical efficacy.

Main Methods:

  • Review of existing literature on GBS vaccine candidates.
  • Analysis of recent developments in immunoassay technologies for vaccine efficacy assessment.

Main Results:

  • Two main vaccine types, protein subunit and capsular polysaccharide conjugate, have been investigated in clinical trials.
  • Advances in immunoassays are crucial for accurately measuring immune responses to GBS vaccines.

Conclusions:

  • Maternal immunization is the most effective strategy to prevent neonatal GBS infections.
  • Continued research and development of GBS vaccines and reliable immunoassays are essential.