Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Unfolded Protein Response01:37

The Unfolded Protein Response

6.4K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
6.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.2K
Overview
84.2K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.9K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.3K
Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

2.7K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.7K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

8.8K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.

Cancers·2026
Same author

Cell motility influences microfluidics capturing in scRNA-seq.

Open research Europe·2026
Same author

Characteristics of T-Cells Expressing IL-37 and Its Receptors in Inflammatory Bowel Disease.

International journal of molecular sciences·2026
Same author

Author Correction: Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review.

Communications medicine·2025
Same author

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Single-cell and Spatial Transcriptomics Illuminate Bat Immunity and Barrier Tissue Evolution.

Molecular biology and evolution·2025
Same journal

Research advances and application prospects of CAR-T therapy in the treatment of age-related diseases.

Frontiers in immunology·2026
Same journal

Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Frontiers in immunology·2026
Same journal

Modified treatment protocol for pediatric systemic lupus erythematosus-associated hemophagocytic lymphohistiocytosis with central nervous system involvement: a case report.

Frontiers in immunology·2026
Same journal

Exploratory characterization of IgG1/IgG4 glycosylation and monocyte-derived dendritic cell responses in esophageal squamous cell carcinoma.

Frontiers in immunology·2026
Same journal

JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases.

Frontiers in immunology·2026
Same journal

Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K

Immune Cell Dynamics Unfolded by Single-Cell Technologies.

Daniel J Kunz1,2,3, Tomás Gomes3, Kylie R James3

  • 1Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom.

Frontiers in Immunology
|July 13, 2018
PubMed
Summary
This summary is machine-generated.

Single-cell technologies are revolutionizing immune system research by revealing cellular dynamics and relationships. This review explores current methods and future advancements for understanding immune cell plasticity and fate.

Keywords:
FACScell differentiationcell fatelineage reconstructionmulti-omicsscRNA-seqsingle-celltrajectory inference

More Related Videos

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

6.0K
Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

15.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K
Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

6.0K
Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

15.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Genomics

Background:

  • The immune system undergoes continuous remodelling throughout life.
  • Cellular phenotypes change in response to disease and memory formation.
  • Single-cell technologies offer high-resolution insights into cellular complexity.

Purpose of the Study:

  • To review single-cell approaches for studying immune system dynamics.
  • To discuss cellular plasticity and fate commitment in the immune system.
  • To provide an outlook on future technological developments in the field.

Main Methods:

  • Review of current single-cell experimental techniques (e.g., scRNA-seq).
  • Discussion of computational methods for analyzing single-cell data.
  • Synthesis of existing literature on immune cell dynamics.

Main Results:

  • Single-cell analysis reveals intricate relationships between immune cell types and states.
  • Insights into immune cell plasticity and the commitment of cell fates are provided.
  • Current methods enable detailed molecular characterization of immune cells.

Conclusions:

  • Single-cell technologies are crucial for understanding immune system complexity.
  • Future technological advancements will further enhance our comprehension of immune cell behavior.
  • This field holds significant promise for disease research and therapeutic development.