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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

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958

Coronary Artery Disease Presentation and Its Association with Shortened Activated Partial Thromboplastin Time

Maryam Sotoudeh Anvari1, Mojgan Tavakoli1, Masoumeh Lotfi-Tokaldany1

  • 1Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

The Journal of Tehran Heart Center
|July 13, 2018
PubMed

Insights

Patients with ST-segment-elevation myocardial infarction (STEMI) showed lower activated partial thromboplastin time (APTT) levels. APTT may predict coronary stenosis severity in patients undergoing angiography.

Area of Science:

  • Cardiology
  • Clinical Laboratory Science
  • Diagnostic Medicine

Background:

  • Standard coagulation screening tests are crucial in clinical diagnostics.
  • The relationship between clinical presentation and coagulation parameters in suspected coronary artery disease (CAD) lacks clear evidence.
  • Investigating coagulation profiles can aid in understanding disease severity.

Purpose of the Study:

  • To investigate the association between clinical presentations of coronary artery disease and standard coagulation parameters.
  • To determine if coagulation tests can predict the extent and severity of coronary stenosis.

Main Methods:

  • A cross-sectional study involving 539 patients undergoing coronary angiography.
  • Patients were categorized by clinical presentation: STEMI, non-STEMI, unstable angina, and stable angina.
  • Prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (APTT) were measured pre-angiography.

Main Results:

  • No significant differences in PT or INR were observed across clinical presentation groups.
  • Activated partial thromboplastin time (APTT) was significantly lower in patients with ST-segment-elevation myocardial infarction (STEMI) and non-STEMI compared to angina groups.
  • Adjusted analysis confirmed a significant association between clinical presentation and APTT, with lower APTT linked to more severe presentations (OR for 5s increase in APTT = 1.661, p=0.003).

Conclusions:

  • Patients presenting with STEMI exhibited the lowest APTT values, while stable angina patients had the highest.
  • Activated partial thromboplastin time (APTT) may serve as a predictive marker for the extent and severity of coronary stenosis in patients undergoing coronary angiography.
  • Further research is warranted to validate APTT's role in predicting CAD severity.

Keywords:
Blood coagulation testsCoronary artery diseaseMyocardial infarctionPartial thromboplastin timeProthrombin time

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