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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Crystal Field Theory
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Oncosis-inducing cyclometalated iridium(iii) complexes.

Ruilin Guan1, Yu Chen1, Leli Zeng1,2

  • 1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry , School of Chemistry , Sun Yat-Sen University , Guangzhou , 510275 , P. R. China .

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|July 13, 2018
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Summary

Researchers developed novel iridium complexes that induce oncosis, a cell death pathway distinct from apoptosis. These complexes show promise in overcoming drug-resistance in cancer therapy by targeting resistant cancer cells.

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Area of Science:

  • Biochemistry
  • Oncology
  • Medicinal Chemistry

Background:

  • Oncosis is a programmed cell death (PCD) pathway distinct from apoptosis, with potential to overcome cancer drug-resistance.
  • Tumor resistance to apoptosis is a significant challenge in cancer treatment.
  • Limited research exists on drugs that specifically induce oncosis compared to other PCD forms.

Purpose of the Study:

  • To synthesize novel mitochondria-targeting cyclometalated Iridium(III) complexes.
  • To investigate the potential of these complexes to induce oncosis in drug-resistant cancer cells.
  • To evaluate the cytotoxicity of these complexes against various drug-resistant cancer types.

Main Methods:

  • Synthesis of a series of mitochondria-targeting cyclometalated Iridium(III) complexes.
  • Activation of oncosis-specific proteins (porimin and calpain) in cisplatin-resistant A549R cells.
  • Cytotoxicity assays against a panel of drug-resistant cancer cell lines.

Main Results:

  • The synthesized Iridium(III) complexes successfully activated oncosis-specific proteins.
  • These complexes demonstrated significant cytotoxicity against multiple drug-resistant cancer types.
  • This study presents the first metallo-compounds shown to induce oncosis in drug-resistant cancer cells.

Conclusions:

  • Novel Iridium(III) complexes can effectively induce oncosis in drug-resistant cancer cells.
  • These findings offer a new therapeutic strategy to combat cancer drug-resistance.
  • Further development of these complexes could lead to new anti-cancer drugs.