Related Experiment Video

Updated: Feb 7, 2026

Isolation and Purification of Murine Cardiac Pericytes
10:49

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

10.0K

Tissue Specific Origin, Development, and Pathological Perspectives of Pericytes

Tomoko Yamazaki1,2, Yoh-Suke Mukouyama1

  • 1Laboratory of Stem Cell and Neuro-Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, Bethesda, MD, United States.

Frontiers in Cardiovascular Medicine
|July 13, 2018
PubMed

Insights

Pericytes, crucial for blood vessel development and the blood-brain barrier, exhibit diverse origins and potential, varying by tissue and context. Understanding pericyte heterogeneity is key to addressing central nervous system diseases.

Area of Science:

  • Vascular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Pericytes are mural cells integral to blood vessel maturation and the blood-brain barrier (BBB).
  • Pericyte deficiency is linked to various central nervous system (CNS) diseases, including neurodegenerative disorders.
  • The developmental origins and phenotypic diversity of pericytes are not fully understood.

Purpose of the Study:

  • To review recent findings on pericyte identification and origins.
  • To explore the heterogeneity of pericytes in development and adulthood.
  • To discuss the differentiation potential and pathological roles of pericytes.

Main Methods:

  • Review of recent scientific literature on pericyte biology.
  • Analysis of studies focusing on pericyte markers and origins.
  • Examination of research on pericyte differentiation and involvement in disease.

Main Results:

  • Pericyte origins are tissue-specific and vary during development and in adults.
  • Pericytes display phenotypic heterogeneity dependent on tissue and context.
  • Evidence suggests pericytes possess differentiation potential, though in vivo capacity requires further study.

Conclusions:

  • Pericytes are a heterogeneous cell population with diverse origins and functions.
  • Understanding pericyte heterogeneity is vital for advancing CNS disease research.
  • Further investigation into pericyte differentiation and in vivo roles is warranted.

Keywords:
developmentdifferentiation capacityheterogeneityoriginpericyte

More Related Videos

Perspectives on Neuroscience26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
A High Output Method to Isolate Cerebral Pericytes from Mouse06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

9.1K

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Sustainable Development01:43

Sustainable Development

As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
376
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
838
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K