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D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels
Yeonoh Shin1,2, Rutika Kokate1, Vilas Desai1
1Department of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University.
Drug Discoveries & Therapeutics
|July 13, 2018
Summary
Polymeric gels like HPMC, HPC, MC, and PF-127 show potential for sustained nasal delivery of D-cycloserine (DCS). These formulations enhance drug viscosity and release, aiding anxiety disorder treatment.
Area of Science:
- Pharmacology
- Materials Science
- Drug Delivery
Background:
- D-cycloserine (DCS) is a partial agonist at N-methyl-D-aspartate (NMDA) receptors.
- DCS is utilized as an enhancer for exposure therapy in treating anxiety disorders.
Purpose of the Study:
- To evaluate the feasibility of using polymeric gels to improve D-cycloserine (DCS) nasal formulation.
- To investigate the impact of gel viscosity on nasal residence time and sustained DCS release in vitro.
Main Methods:
- Formulation of nasal gels using Hydroxypropyl methylcellulose (HPMC), Hydroxypropyl cellulose (HPC), Methyl cellulose (MC), and Pluronic F-127 (PF-127) at varying concentrations.
- Analysis of gel properties including pH, viscosity, and in vitro D-cycloserine (DCS) release over 24 hours.
Main Results:
- All tested polymeric gels (HPMC, HPC, MC, PF-127) demonstrated sustained D-cycloserine (DCS) release over a 24-hour period.
- Different release rates were observed among the various gel formulations.
- The polymeric gels effectively increased formulation viscosity, suggesting prolonged nasal residence time.
Conclusions:
- Hydroxypropyl methylcellulose (HPMC), Hydroxypropyl cellulose (HPC), Methyl cellulose (MC), and Pluronic F-127 (PF-127) are suitable for developing sustained-release nasal gel formulations of D-cycloserine (DCS).
- These polymers can enhance DCS nasal delivery, potentially improving anxiety disorder treatment efficacy.
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