[Estimation of glomerular filtration rate with creatinine]

Area of Science:

• Nephrology
• Clinical Chemistry
• Biomarker Analysis

Background:

• Glomerular filtration rate (GFR) is the primary indicator of overall kidney function.
• Accurate GFR estimation is vital for effective clinical management and treatment decisions.
• Reference methods for GFR measurement are complex and not routinely accessible.

Purpose of the Study:

• To highlight the importance of GFR estimation in clinical practice.
• To discuss the utility of endogenous biomarkers for routine GFR assessment.
• To compare the accuracy of different creatinine measurement methods for GFR estimation.

Main Methods:

• Utilizing creatinine as the primary endogenous biomarker for GFR estimation.
• Employing creatinine clearance and plasma creatinine concentration-based formulas.
• Comparing enzymatic and Jaffe methods for creatinine measurement.

Main Results:

• Creatinine is the most frequently used biomarker for estimating GFR.
• Enzymatic methods for creatinine measurement yield more accurate results than Jaffe methods.
• The accuracy advantage of enzymatic methods is particularly notable at normal and low creatinine levels.

Conclusions:

• Accurate GFR estimation is essential for clinical practice.
• Enzymatic creatinine assays are superior to Jaffe methods for precise GFR assessment.
• Routine GFR evaluation should prioritize accurate creatinine measurement techniques.