Related Experiment Video
Updated: Feb 7, 2026
06:39
Author Spotlight: Design and Evaluation of Au-Electroplated Carbon Fiber Cloth Electrodes for Hydrogen Peroxide Fuel Cells
Published on: October 20, 2023
3.9K
Lipid Peroxidation Adds Fuel to Pyr(optosis)
Ashley J Russo1, Vijay A K Rathinam1
1Department of Immunology, UConn Health School of Medicine, 263 Farmington Ave., Farmington, CT 06030, USA.
Cell Host & Microbe
|July 13, 2018
Summary
Glutathione peroxidase 4 (GPX4) prevents cell damage from lipid peroxidation. New research shows GPX4 inhibits pyroptosis, a cell death pathway, and prevents lethal inflammation during sepsis.
Area of Science:
- Biochemistry
- Cell Biology
- Immunology
Background:
- Glutathione peroxidase 4 (GPX4) is a key antioxidant enzyme.
- GPX4 protects cells against oxidative stress and lipid peroxidation.
Purpose of the Study:
- To investigate the role of GPX4 in cell death pathways.
- To determine GPX4's function in regulating inflammation, particularly in sepsis.
Main Methods:
- Utilized cell-based assays to study pyroptosis.
- Investigated the enzymatic activity of GPX4 in relation to inflammatory responses.
Main Results:
- GPX4 acts as a negative regulator of the pyroptotic cell death pathway.
- GPX4 significantly inhibits inflammation associated with lethal sepsis.
Conclusions:
- GPX4 plays a critical role in preventing excessive cell death and inflammation.
- GPX4 is a potential therapeutic target for managing sepsis and inflammatory diseases.
More Related Videos
Related Concept Videos
03:12Batteries and Fuel Cells
31.0K
A battery is a galvanic cell that is used as a source of electrical power for specific applications. Modern batteries exist in a multitude of forms to accommodate various applications, from tiny button batteries such as those that power wristwatches to the very large batteries used to supply backup energy to municipal power grids. Some batteries are designed for single-use applications and cannot be recharged (primary cells), while others are based on conveniently reversible cell reactions that...
31.0K
01:38What are Lipids?
220.7K
Overview
220.7K
01:31What are Lipids?
11.4K
Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms. The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
11.4K
01:06Lipid Digestion
99.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.6K
03:38Structure of Lipids
99.1K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
99.1K
02:23Autoxidation of Ethers to Peroxides and Hydroperoxides
9.6K
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
9.6K