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Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
Published on: March 10, 2023
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Crystal-Induced Arthritides in the Elderly: An Update.
Hossam El-Zawawy1, Brian F Mandell2
1Cleveland Clinic Lerner College of Medicine (CCLCM), Case Western Reserve University, Cleveland, OH, USA; Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.
Rheumatic Diseases Clinics of North America
|July 14, 2018
Summary
Gout prevalence rises with age, often presenting atypically in older adults. Maintaining serum urate below 6.8 mg/dL is key to dissolving deposits and preventing gout flares.
Area of Science:
- Rheumatology
- Geriatric Medicine
- Clinical Biochemistry
Background:
- Gout prevalence increases with age.
- Serum urate supersaturation leads to crystal deposition in joints.
- Elderly gout presentation is frequently atypical, complicating diagnosis.
Purpose of the Study:
- To highlight diagnostic and therapeutic challenges of gout in the elderly.
- To emphasize the importance of urate-lowering therapy for gout management.
Main Methods:
- Review of clinical presentation and management strategies for gout in older adults.
- Discussion of urate solubility thresholds and their clinical implications.
Main Results:
- Elderly patients present unique challenges due to comorbidities and atypical symptoms.
- Treatment decisions are complex, with potentially limited therapeutic options.
- Maintaining serum urate below 6.8 mg/dL is crucial for preventing urate crystal deposition.
Conclusions:
- Effective gout management in the elderly requires addressing atypical presentations and comorbidities.
- Achieving and maintaining low serum urate levels below the saturation point is essential for preventing recurrent gout attacks and promoting urate crystal dissolution.
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