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Updated: Feb 7, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells
Michelle L McCully1, Ariadni Kouzeli1, Bernhard Moser1
1Division of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Abstract:
Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (TRM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination).
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