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Cortical thickness analysis in operculo-insular epilepsy.

Sami Obaid1, Alan Tucholka2, Jimmy Ghaziri3

  • 1Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Service de Neurochirurgie, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Neuroimage. Clinical
|July 14, 2018
PubMed
Summary
This summary is machine-generated.

Operculo-insular epilepsy (OIE) shows widespread cortical thinning beyond the insula, unlike temporal lobe epilepsy (TLE). These findings highlight OIE

Keywords:
Cortical thicknessEpilepsyInsulaOperculum

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Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Structural Brain Abnormalities

Background:

  • Temporal lobe epilepsy (TLE) exhibits anomalies beyond the temporal lobe.
  • Operculo-insular epilepsy (OIE) is under-recognized and can mimic TLE.
  • Investigating insular and extra-insular cortical thickness (CT) changes in OIE is crucial.

Purpose of the Study:

  • To investigate insular and extra-insular cortical thickness (CT) changes in patients with operculo-insular epilepsy (OIE).
  • To compare OIE structural anomalies with those in temporal lobe epilepsy (TLE) and healthy controls.
  • To characterize the extent of cortical thinning in OIE.

Main Methods:

  • 3 Tesla MRI T1-weighted acquisition in 14 OIE patients, 9 TLE patients, and 26 healthy controls.
  • Advanced Normalization Tools for anatomical image processing.
  • Two-sided t-tests comparing cortical thickness between OIE vs TLE and OIE vs healthy controls, with corrected p < 0.05 and 250-voxel threshold.

Main Results:

  • OIE patients displayed significant widespread cortical thinning compared to controls, particularly in the ipsilateral insula, peri-rolandic, orbito-frontal, mesiotemporal, and lateral temporal regions.
  • Contralateral cortical shrinkage in OIE was milder and less diffuse.
  • OIE patients showed equal or reduced cortical thickness relative to TLE patients across all analyzed regions, with diffuse thinning predominantly in both insulae and the ipsilateral occipito-temporal area.

Conclusions:

  • Structural anomalies in OIE extend beyond the operculo-insular region.
  • OIE presents distinct patterns of cortical thinning compared to TLE.
  • These findings contribute to a better understanding and characterization of OIE.