Related Experiment Video
Updated: Feb 7, 2026
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
15.2K
Recurrent retroperitoneal soft tissue sarcoma showing drastic reduction after pazopanib administration accompanied by
Kazuki Okubo1, Akio Horiguchi1, Keiichi Ito1
1Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Urology Case Reports
|July 14, 2018
Summary
Pazopanib effectively treated soft tissue sarcoma but caused severe liver dysfunction. Treatment was stopped, liver function recovered, and the tumor regrew, highlighting a critical treatment challenge.
Area of Science:
- Oncology
- Pharmacology
- Hepatology
Background:
- Pazopanib is an oral tyrosine kinase inhibitor used for metastatic renal cell carcinoma and soft tissue sarcoma.
- Soft tissue sarcoma is a rare cancer requiring effective treatment options.
Observation:
- A patient with recurrent retroperitoneal soft tissue sarcoma experienced tumor reduction after pazopanib initiation.
- This response was concurrent with severe liver dysfunction.
Findings:
- Pazopanib administration led to a significant decrease in tumor size.
- Discontinuation of pazopanib and conservative management with hepatoprotectors restored liver function.
- The sarcoma regrew within four months after treatment cessation.
Implications:
- Pazopanib demonstrates efficacy in soft tissue sarcoma but carries a risk of severe hepatotoxicity.
- Careful monitoring of liver function is crucial during pazopanib therapy.
- Further research is needed to optimize pazopanib use and manage its side effects in sarcoma patients.
Related Concept Videos
03:11Oxidation-Reduction Reactions
75.8K
Oxidation–Reduction Reactions
75.8K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.4K
02:36Oxymercuration-Reduction of Alkenes
9.4K
Oxymercuration–reduction of alkenes is one of the major reactions converting alkenes to alcohols. It involves the hydration of alkenes with mercuric acetate in a mixture of tetrahydrofuran and water, forming an organomercury adduct. This is followed by a demercuration step in which the adduct is reduced to an alcohol using sodium borohydride.
9.4K
01:22Block Diagram Reduction
567
The process of deriving the transfer function of a control system often involves reducing its block diagram to a single block. This simplification can be achieved through a series of strategic operations, including relocating branch points and comparators. These operations preserve the overall function of the system while allowing for easier manipulation and combination of blocks.
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
567
01:27Phase I Reactions: Reductive Reactions
604
Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
604
01:17Esters to Alcohols: Hydride Reductions
4.8K
Esters are reduced to primary alcohols when treated with a strong reducing agent like lithium aluminum hydride. The reaction requires two equivalents of the reducing agent and proceeds via an aldehyde intermediate.
Lithium aluminum hydride is a source of hydride ions and functions as a nucleophile. The mechanism proceeds in three steps. Firstly, the nucleophilic hydride ion attacks the carbonyl carbon of the ester to form a tetrahedral intermediate. Subsequently, the carbonyl group re-forms,...
Lithium aluminum hydride is a source of hydride ions and functions as a nucleophile. The mechanism proceeds in three steps. Firstly, the nucleophilic hydride ion attacks the carbonyl carbon of the ester to form a tetrahedral intermediate. Subsequently, the carbonyl group re-forms,...
4.8K